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My Castle Views

Posted by johnnieraz on August 15, 2020 at 7:00 AM

By John Rezell

     As we wrapped around the final switchbacks on the western edge of Castle Rock, the fog lifted from the valley into a bright blue sky like a flock of sparkling stars returning to the Milky Way. Ridgely charged ahead, as she's apt to do, as curious as I was — wondering if we would be graced by the view or fogged in.

     Once we cleared the summit and hiked to the eastern front, Mother Nature rewarded us in grand style. The Sisters peeked over a bank of clouds hanging like a sash around their middriff. We sat and soaked it in, this nearly perfect Saturday morning.

     Oregon gets a terrible rap for its weather, which, Spoiler Alert, is fine with us. It rains, sure, but nowhere near the London-esque manner most people believe. I ride my bike to work every day, and only need to don rain pants a handful of times each year. .

      From June until September, here in the Willamette Valley we see nary a drop of rain. Summers are magificent. The rest of the year, we never let a little rain bother us. Clouds, however, spend a lot of time hanging around here this time of the year.

     So to have a chance to make one of my favorite hikes and be rewarded with my most cherished Oregon image, well, I just couldn't pass that up.

     You can see the majestic Sisters from numerous locations in Eugene, but it's not as though they serve as towering sentinels watching over us. Which makes the fact that they have become my vision of "home" even more confounding. Whenever their peaks pop into view, something stirs deep inside.

     There was a time when Holy Hill, cradled in Wisconsin's Kettle Moraine gave me that jolt. Later the Southern California sunsets across the Pacific and the stunning views of the Flat Irons overlooking Boulder brought me that sizzle.

     These days, the Sisters offer me peace of mind. Home.

     Something about this hike lures me to this viewpoint again and again, after the first visit struck me like a magical spell. It has been our Christmas hike on many occasions that snow levels allow it, and it's the place where I brought my sax to wail one final tribute to Clarence Clemons on his passing.

     We had the mountain to ourselves this Saturday morning, Ridgely and I. Miles from our house, a few thousand feet above it, we spent the morning at home.

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Reply tcsindustryb
5:58 AM on July 3, 2022 
carnosine (beta-alanyl-l-histidine) is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. it is highly concentrated in muscle and brain tissues.needed]

carnosine and carnitine were discovered by russian chemist vladimir gulevich. it has been proven to scavenge reactive oxygen species (ros) as well as alpha-beta unsaturated aldehydes formed from peroxidation of cell membrane fatty acids during oxidative stress. it also buffers ph in muscle cells, and acts as a neurotransmitter in the brain. it is also a zwitterion, a neutral molecule with a positive and negative end.needed]

like carnitine, carnosine is composed of the root word carn, meaning "flesh", alluding to its prevalence in animal protein. there are no plant-based sources of carnosine. therefore, a vegetarian or vegan diet provides little or no carnosine in comparison to the amounts found in a diet that includes meat.

carnosine can chelate divalent metal ions.

carnosine can increase the hayflick limit in human fibroblasts, as well as appearing to reduce the telomere shortening rate. it is also considered as a geroprotector.

carnosine is synthesized in vivo from beta-alanine and histidine. since beta-alanine is the limiting substrate, supplementing just beta-alanine effectively increases the intramuscular concentration of carnosine.

physiological effects
carnosine has a pka value of 6.83, making it a good buffer for the ph range of animal muscles. since beta-alanine is not incorporated into proteins, carnosine can be stored at relatively high concentrations (millimolar). occurring at 17–25 mmol/kg (dry muscle), carnosine (ß-alanyl-l-histidine) is an important intramuscular buffer, constituting 10-20% of the total buffering capacity in type i and ii muscle fibres.